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OR Apache-2.0","homepage":"https://kent-tokyo.github.io/chematic/","keywords":["cheminformatics","wasm","webassembly","smiles","chemistry"],"repository":{"url":"git+https://github.com/kent-tokyo/chematic.git","type":"git"},"description":"WebAssembly bindings for chematic — use chematic from JavaScript/TypeScript","maintainers":[{"name":"kent-tokyo","email":"ke.tanabe@gmail.com"}],"readme":"# chematic-wasm\n\nWebAssembly bindings for [chematic](https://github.com/kent-tokyo/chematic), a pure-Rust cheminformatics library.\n\nPublished to npm as [`@kent-tokyo/chematic`](https://www.npmjs.com/package/@kent-tokyo/chematic).\n\nThe current workspace line is 1.0.28. The binding keeps bounded parsing,\ntyped failures, and opt-in `embed_pipeline_v2_json`; 3D/MMFF94 behavior remains\nExperimental and is not a claim of full RDKit parity.\n\n## Installation\n\n```sh\nnpm install @kent-tokyo/chematic\n```\n\n## Features\n\n- Parse SMILES strings into molecule handles\n- Molecular descriptors: MW, TPSA, LogP, Fsp3, QED, exact mass, rotatable bonds, HBD/HBA, aromatic ring count, Labute ASA\n- Drug-likeness filters: Lipinski, Veber, Egan, REOS, Ghose\n- EState indices (Hall & Kier 1991): per-atom values, sum/max/min\n- Gasteiger-Marsili PEOE partial charges: per-heavy-atom charges\n- VSA descriptors: SlogP_VSA (×12), SMR_VSA (×10), PEOE_VSA (×14)\n- SA score: synthetic accessibility estimate [1, 10]\n- Functional group identification (Ertl 2017 IFG)\n- Canonical SMILES generation\n- ECFP4/6, AtomPair, Torsion, path, and RDKit-compatible RDK fingerprints\n  with Tanimoto similarity\n- BRICS fragment count\n- SDF/MOL block parsing, including bounded resumable `sdf_records_batch_json`,\n  `xyz_frames_batch_json`, and `extxyz_frames_batch_json` manifests with\n  deterministic input indices and partial/complete status; bounded malformed\n  XYZ frames are grouped inline as rejected records when a later count-line\n  boundary is recoverable (core file-backed readers remain fail-stop)\n- Bounded topology parsing for CML (`mol_from_cml_strict` provides the opt-in\n  non-empty, balanced, single-root boundary), ChemicalJSON (`mol_from_cjson`), MolJSON,\n  CDXML, MOL2, and PDB/mmCIF\n- Index-aligned wildcard/R-group inspection with\n  `MolHandle.atom_pseudo_labels_json()` and immutable edits through\n  `mol_with_atom_pseudo_label`; labels are bounded to `*`, `R`, and\n  `R1..R9999`\n- PDBx/mmCIF, PQR, QCSchema JSON, ORCA input/output, Gaussian Cube, OpenDX,\n  and LAMMPS data/dump I/O (JSON-based bindings; see `format_io.rs`)\n- Topological descriptors: Wiener index, Hall-Kier κ, χ connectivity indices, Bertz CT\n- Shape descriptors (with 3D coordinates): PMI, NPR, radius of gyration, asphericity\n- 2D SVG depiction with CPK colors and atom/bond highlighting\n- SVG grid layout for multiple molecules\n- Reaction SMILES/SMIRKS parsing and transform\n- Add/remove explicit hydrogens\n- `embed_pipeline_v2_json`: torsion-knowledge-aware 3D embedding + stereo\n  verification/repair + policy-gated force field, mirroring the Python\n  `Mol.embed_pipeline_v2()` binding — opt-in, not a default 3D API\n  ([usage](#3d-embedding-embed_pipeline_v2_json))\n\n## Usage\n\nThe generated handle declarations include `Symbol.dispose` for explicit\nresource release. TypeScript consumers should include `ESNext.Disposable` in\ntheir `tsconfig.json` `lib` list (in addition to their normal browser or Node\nlibraries):\n\n```json\n{\n  \"compilerOptions\": {\n    \"lib\": [\"ES2022\", \"DOM\", \"ESNext.Disposable\"]\n  }\n}\n```\n\n```js\nimport init, {\n  parse_smiles,\n  tanimoto_ecfp4,\n  tanimoto_atom_pair,\n  tanimoto_torsion,\n  brics_fragment_count,\n  gasteiger_charges_json,\n  slogp_vsa_json,\n  smr_vsa_json,\n  peoe_vsa_json,\n  identify_functional_groups,\n} from '@kent-tokyo/chematic';\n\nawait init();\n\nconst mol = parse_smiles('CC(=O)Oc1ccccc1C(=O)O'); // aspirin\n\n// Descriptors\nconsole.log(mol.atom_count());          // 13\nconsole.log(mol.molecular_weight());    // ~180.16\nconsole.log(mol.formula());             // \"C9H8O4\"\nconsole.log(mol.tpsa());               // ~63.6\nconsole.log(mol.logp_crippen());        // ~1.2\nconsole.log(mol.fsp3());               // ~0.111\nconsole.log(mol.qed());                // drug-likeness score [0, 1]\nconsole.log(mol.exact_mass());         // ~180.042\nconsole.log(mol.hbd_count());          // 1\nconsole.log(mol.hba_count());          // 4\nconsole.log(mol.rotatable_bond_count()); // 2 (RDKit Lipinski definition)\nconsole.log(mol.aromatic_ring_count()); // 1\nconsole.log(mol.lipinski_passes());     // true\nconsole.log(mol.canonical_smiles());    // canonical SMILES string\n\n// BRICS fragmentation\nconsole.log(brics_fragment_count(mol)); // ≥ 2\n\n// Fingerprint similarity\nconst caffeine = parse_smiles('Cn1cnc2c1c(=O)n(c(=O)n2C)C');\nconsole.log(tanimoto_ecfp4(mol, caffeine));    // ECFP4 Tanimoto\nconsole.log(tanimoto_atom_pair(mol, caffeine)); // AtomPair Tanimoto\nconsole.log(tanimoto_torsion(mol, caffeine));   // Torsion Tanimoto\n```\n\n### Node.js\n\nThe published package is built with wasm-pack's `web` target. In a browser,\n`await init()` locates the adjacent WASM asset. Node does not fetch `file:`\nURLs, so pass the asset bytes explicitly:\n\n```js\nimport { readFile } from 'node:fs/promises';\nimport init, { parse_smiles } from '@kent-tokyo/chematic';\n\nconst wasm = await readFile(new URL(\n  './node_modules/@kent-tokyo/chematic/chematic_wasm_bg.wasm',\n  import.meta.url,\n));\nawait init({ module_or_path: wasm });\nconst mol = parse_smiles('c1ccccc1');\nconsole.log(mol.formula()); // C6H6\nmol.free();\n```\n\n```js\n// Sprint Q: New descriptors (v0.1.15)\nconsole.log(mol.sa_score());                     // synthetic accessibility [1,10]\nconsole.log(mol.labute_asa());                   // Labute approx. surface area (Å²)\n\n// Gasteiger partial charges (per heavy atom)\nconst charges = JSON.parse(gasteiger_charges_json(mol));\nconsole.log(charges); // [-0.08, 0.12, -0.43, ...]\n\n// Explicit RDKit-compatibility descriptor profile (kept separate from the\n// historical native get_descriptors_json() profile)\nconst rdkitDescriptors = JSON.parse(get_rdkit_descriptors_json(mol));\nconsole.log(rdkitDescriptors.aromatic_ring_count);\n\n// VSA descriptor bins\nconst slogpVsa = JSON.parse(slogp_vsa_json(mol));\nconst smrVsa   = JSON.parse(smr_vsa_json(mol));\nconst peoeVsa  = JSON.parse(peoe_vsa_json(mol));\n\n// Functional group identification\nconst ifg = JSON.parse(identify_functional_groups(mol));\nconsole.log(ifg); // [{\"atoms\":[1,2,3],\"types\":\"OC=O\"}, ...]\n```\n\n### 3D embedding (`embed_pipeline_v2_json`)\n\nOpt-in — does not change behavior of any existing 3D API (`generate_coords`,\n`generate_and_minimize_*`, etc.), which remain the defaults.\n\n```js\nconst response = JSON.parse(embed_pipeline_v2_json(mol, JSON.stringify({\n  embedSeed: 7,\n  maxAttempts: 8,\n  embedTimeoutMs: null,\n  useExpTorsions: false,\n  useSmallRingTorsions: false,\n  useMacrocycleTorsions: false,\n  useMacrocycle14Bounds: false,\n  includeLegacyTorsionHeuristic: false,\n  stereoPolicy: \"ignore\",\n  failOnUnevaluableStereo: false,\n  forceFieldPolicy: \"none\",\n  forceFieldMaxIterations: 200,\n  gateMmff94TorsionOop: false,\n  gateMmff94StretchBend: false,\n  ringTorsionPolicy: \"fail_closed\",\n  totalTimeoutMs: null,\n  enforceChirality: false,\n  expandImplicitHThroughPipeline: false,\n})));\n// response.ok, response.result / response.error — same shape as\n// Mol.embed_pipeline_v2() in the Python binding.\n```\n\nFor ring-fused declared stereocenters (e.g. testosterone, cholesterol) that\n`enforceChirality` alone can't repair, `stereoPolicy: \"repair_and_verify\"` +\n`enforceChirality: true` + `expandImplicitHThroughPipeline: true` are needed\n*together* (issue #291/#383) — `pipeline_v2_stereo_safe_config_json` builds\nthat exact combination so a caller can't set one and forget another:\n\n```js\nconst configResponse = JSON.parse(pipeline_v2_stereo_safe_config_json(\n  \"mmff94_with_uff_fallback\", \"fail_closed\"\n));\n// configResponse.ok, configResponse.config (or configResponse.error, same\n// shape as embed_pipeline_v2_json's own error) — modify configResponse.config\n// (e.g. a different embedSeed) before passing it to embed_pipeline_v2_json.\nconst response = JSON.parse(\n  embed_pipeline_v2_json(mol, JSON.stringify(configResponse.config))\n);\n```\n\nVerified working end-to-end under real WASM (both `wasm-pack --target nodejs`\nand `--target web`, the latter being what this package's npm build actually\nuses) — success, typed-failure, and typed-timeout paths all return real\nresults. `embedTimeoutMs`/`totalTimeoutMs` use a monotonic clock that's\nportable across native and `wasm32-unknown-unknown`\n([`web-time`](https://crates.io/crates/web-time), backed by\n`Performance.now()` in the browser); this does not claim identical wall-clock\nprecision across every JS engine, only that the value is finite, non-negative,\nand enforced correctly on all of them.\n\n`nearest_neighbors_json` keeps its historical chematic-native ECFP4 profile.\nFor the separately named RDKit-compatible Morgan profile, use\n`rdkit_nearest_neighbors_json(querySmiles, dbSmilesJson, k)`. It returns the\nsame `{index, tanimoto}` shape and reports preprocessing failures without\nsilently falling back to native ECFP4.\n\nFor repeated queries, construct `new RdkitSearchIndex(dbSmilesJson)` once and\ncall `index.search_json(querySmiles, k)`. The prepared index is intended for\nchunked libraries up to the WASM batch limit and applies the same fail-closed\nRDKit-compatible profile without rebuilding database fingerprints per query.\n\n## V3000 SGROUP syntax view\n\n`v3000_sgroups_json(block)` exposes bounded, typed SGROUP syntax without\nexpanding polymer or Markush semantics. It preserves source order for unknown\nattributes and returns `kindToken` for unknown group kinds. Group IDs, parent\nreferences, atom references, and grouped-field counts are validated before\nJSON is returned.\n\n```js\nconst groups = JSON.parse(v3000_sgroups_json(v3000Block));\n// [{ id, kind, parentId, atomIds, attributes, kindToken? }]\n```\n\nThis is a syntax-level API; it does not claim polymer expansion, Markush\ninterpretation, or cross-engine semantic compatibility.\n\n## Bundle size\n\nThe published v1.0.15 npm WASM asset is **4,005,280 bytes raw / 1,460,499\nbytes gzip**. Bundle size depends on features and toolchain; see the\n[published-package scorecard](../../benchmarks/2026-09-16-official-rdkit-js-isolated-browser-v1.0.15.md)\nfor package versions, digests, tools, and reproduction steps.\n\nPNG rasterization (`tiny_skia`) is excluded from the WASM build — use SVG output instead. All SVG depiction APIs remain fully available.\n\n## Versioned document binding boundary\n\nThe `*_v1` document APIs provide a stable JSON boundary for downstream editors:\n\n```js\nconst parsed = JSON.parse(reaction_document_json_v1(JSON.stringify(document)));\nconst edited = JSON.parse(edit_reaction_document_json_v1(\n  JSON.stringify(parsed),\n  JSON.stringify({ kind: \"set_step_condition\", step_id: \"step-1\", key: \"temperature\", value: \"25 C\" }),\n));\n\nconst cdxmlEnvelope = JSON.parse(cdxml_document_json_v1(cdxml));\nconst cdxmlAgain = cdxml_document_from_json_v1(JSON.stringify(cdxmlEnvelope));\n```\n\n`cdxml_document_json_v1` retains the exact `source` string and returns a\nstructural `document` summary with opaque objects and `diagnostics`. Use\n`edit_cdxml_document_json_v1` for bounded page/object edits; it reparses the\nresult before returning. Errors are JSON-shaped with stable `code`, `path`, and\n`message` fields (`malformed_input`, `resource_limit`,\n`unsupported_construct`, `lossy_conversion`, or `serialization_error`).\n`reaction_document_to_rxn_v1` and `cdxml_document_projection_json_v1` reject\nlossy legacy projections with `lossy_conversion` diagnostics. These APIs do not claim\nmechanism correctness, product prediction, complete stoichiometry, or full\nChemDraw/RXN compatibility.\n\n## Building from source\n\n```sh\nwasm-pack build --target bundler --release\n```\n","readmeFilename":"README.md"}