import { Extension } from './Extension.js';
import { FhirPrimitive } from './FhirPrimitive.js';
export interface MolecularSequence_Relative_Edit {
    /**
     * @description Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.
     * @short Unique id for inter-element referencing
     */
    id?: string;
    /**
     * @description May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
     * @comment There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
     * @short Additional content defined by implementations
     */
    extension?: Extension[];
    /**
     * @description May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained andor the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.
  
  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
     * @comment There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
     * @short Extensions that cannot be ignored even if unrecognized
     */
    modifierExtension?: Extension[];
    /**
     * @description Start position of the edit on the starting sequence. If the coordinate system is either 0-based or 1-based, then start position is inclusive.
     * @short Start position of the edit on the starting sequence
     */
    start?: FhirPrimitive<number>;
    /**
     * @description End position of the edit on the starting sequence. If the coordinate system is 0-based then end is exclusive and does not include the last position. If the coordinate system is 1-base, then end is inclusive and includes the last position.
     * @short End position of the edit on the starting sequence
     */
    end?: FhirPrimitive<number>;
    /**
     * @description Allele that was observed. Nucleotide(s)amino acids from start position of sequence to stop position of sequence on the positive (+) strand of the observed sequence. When the sequence type is DNA, it should be the sequence on the positive (+) strand. This will lay in the range between variant.start and variant.end.
     * @short Allele that was observed
     */
    replacementSequence?: FhirPrimitive<string>;
    /**
     * @description Allele in the starting sequence. Nucleotide(s)amino acids from start position of sequence to stop position of sequence on the positive (+) strand of the starting sequence. When the sequence  type is DNA, it should be the sequence on the positive (+) strand. This will lay in the range between variant.start and variant.end.
     * @short Allele in the starting sequence
     */
    replacedSequence?: FhirPrimitive<string>;
}
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