import { CodeableConcept } from './CodeableConcept.js';
import { CodeableReference } from './CodeableReference.js';
import { Coding } from './Coding.js';
import { DeviceDefinition } from './DeviceDefinition.js';
import { DocumentReference } from './DocumentReference.js';
import { Extension } from './Extension.js';
import { FhirPrimitive } from './FhirPrimitive.js';
import { Identifier } from './Identifier.js';
import { ManufacturedItemDefinition } from './ManufacturedItemDefinition.js';
import { MarketingStatus } from './MarketingStatus.js';
import { MedicinalProductDefinition_Characteristic } from './MedicinalProductDefinition_Characteristic.js';
import { MedicinalProductDefinition_Contact } from './MedicinalProductDefinition_Contact.js';
import { MedicinalProductDefinition_CrossReference } from './MedicinalProductDefinition_CrossReference.js';
import { MedicinalProductDefinition_Name } from './MedicinalProductDefinition_Name.js';
import { MedicinalProductDefinition_Operation } from './MedicinalProductDefinition_Operation.js';
import { Meta } from './Meta.js';
import { Narrative } from './Narrative.js';
import { Reference } from './Reference.js';
import { ResearchStudy } from './ResearchStudy.js';
import { Resource } from './Resource.js';
import { SubstanceDefinition } from './SubstanceDefinition.js';
export interface MedicinalProductDefinition {
    /**
     * @description The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.
     * @comment Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case.
     * @short Logical id of this artifact
     */
    id?: string;
    /**
     * @description The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.
     * @short Metadata about the resource
     */
    meta?: Meta;
    /**
     * @description A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.
     * @comment Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers andor specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.
     * @short A set of rules under which this content was created
     */
    implicitRules?: FhirPrimitive<string>;
    /**
     * @description The base language in which the resource is written.
     * @comment Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies  to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).
     * @short Language of the resource content
     */
    language?: FhirPrimitive<string>;
    /**
     * @description A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.
     * @comment Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied).  This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later.
     * @short Text summary of the resource, for human interpretation
     */
    text?: Narrative;
    /**
     * @description These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides contextmeaning.
     * @comment This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels.
     * @short Contained, inline Resources
     */
    contained?: Resource[];
    /**
     * @description May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.
     * @comment There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
     * @short Additional content defined by implementations
     */
    extension?: Extension[];
    /**
     * @description May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it andor the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.
  
  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).
     * @comment There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions.  The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.
     * @short Extensions that cannot be ignored
     */
    modifierExtension?: Extension[];
    /**
     * @description Business identifier for this product. Could be an MPID. When in development or being regulated, products are typically referenced by official identifiers, assigned by a manufacturer or regulator, and unique to a product (which, when compared to a product instance being prescribed, is actually a product type). See also MedicinalProductDefinition.code.
     * @short Business identifier for this product. Could be an MPID
     */
    identifier?: Identifier[];
    /**
     * @description Regulatory type, e.g. Investigational or Authorized.
     * @short Regulatory type, e.g. Investigational or Authorized
     */
    type?: CodeableConcept;
    /**
     * @description If this medicine applies to human or veterinary uses.
     * @short If this medicine applies to human or veterinary uses
     */
    domain?: CodeableConcept;
    /**
     * @description A business identifier relating to a specific version of the product, this is commonly used to support revisions to an existing product.
     * @short A business identifier relating to a specific version of the product
     */
    version?: FhirPrimitive<string>;
    /**
     * @description The status within the lifecycle of this product record. A high-level status, this is not intended to duplicate details carried elsewhere such as legal status, or authorization status.
     * @short The status within the lifecycle of this product record
     */
    status?: CodeableConcept;
    /**
     * @description The date at which the given status became applicable.
     * @short The date at which the given status became applicable
     */
    statusDate?: FhirPrimitive<string>;
    /**
     * @description General description of this product.
     * @short General description of this product
     */
    description?: FhirPrimitive<string>;
    /**
     * @description The dose form for a single part product, or combined form of a multiple part product. This is one concept that describes all the components. It does not represent the form with components physically mixed, if that might be necessary, for which see (AdministrableProductDefinition.administrableDoseForm).
     * @short The dose form for a single part product, or combined form of a multiple part product
     */
    combinedPharmaceuticalDoseForm?: CodeableConcept;
    /**
     * @description The path by which the product is taken into or makes contact with the body. In some regions this is referred to as the licenced or approved route. See also AdministrableProductDefinition resource. MedicinalProductDefinition.route is the same concept as AdministrableProductDefinition.routeOfAdministration.code, and they cannot be used together.
     * @short The path by which the product is taken into or makes contact with the body
     */
    route?: CodeableConcept[];
    /**
     * @description Description of indication(s) for this product, used when structured indications are not required. In cases where structured indications are required, they are captured using the ClinicalUseDefinition resource. An indication is a medical situation for which using the product is appropriate.
     * @short Description of indication(s) for this product, used when structured indications are not required
     */
    indication?: FhirPrimitive<string>;
    /**
     * @description The legal status of supply of the medicinal product as classified by the regulator.
     * @short The legal status of supply of the medicinal product as classified by the regulator
     */
    legalStatusOfSupply?: CodeableConcept;
    /**
     * @description Whether the Medicinal Product is subject to additional monitoring for regulatory reasons, such as heightened reporting requirements.
     * @short Whether the Medicinal Product is subject to additional monitoring for regulatory reasons
     */
    additionalMonitoringIndicator?: CodeableConcept;
    /**
     * @description Whether the Medicinal Product is subject to special measures for regulatory reasons, such as a requirement to conduct post-authorization studies.
     * @short Whether the Medicinal Product is subject to special measures for regulatory reasons
     */
    specialMeasures?: CodeableConcept[];
    /**
     * @description If authorised for use in children, or infants, neonates etc.
     * @short If authorised for use in children
     */
    pediatricUseIndicator?: CodeableConcept;
    /**
     * @description Allows the product to be classified by various systems, commonly WHO ATC.
     * @short Allows the product to be classified by various systems
     */
    classification?: CodeableConcept[];
    /**
     * @description Marketing status of the medicinal product, in contrast to marketing authorization. This refers to the product being actually 'on the market' as opposed to being allowed to be on the market (which is an authorization).
     * @short Marketing status of the medicinal product, in contrast to marketing authorization
     */
    marketingStatus?: MarketingStatus[];
    /**
     * @description Package type for the product. See also the PackagedProductDefinition resource.
     * @short Package type for the product
     */
    packagedMedicinalProduct?: CodeableConcept[];
    /**
     * @description Types of medicinal manufactured items andor devices that this product consists of, such as tablets, capsule, or syringes. Used as a direct link when the item's packaging is not being recorded (see also PackagedProductDefinition.package.containedItem.item).
     * @short Types of medicinal manufactured items andor devices that this product consists of, such as tablets, capsule, or syringes
     */
    comprisedOf?: Reference<ManufacturedItemDefinition | DeviceDefinition>[];
    /**
     * @description The ingredients of this medicinal product - when not detailed in other resources. This is only needed if the ingredients are not specified by incoming references from the Ingredient resource, or indirectly via incoming AdministrableProductDefinition, PackagedProductDefinition or ManufacturedItemDefinition references. In cases where those levels of detail are not used, the ingredients may be specified directly here as codes.
     * @short The ingredients of this medicinal product - when not detailed in other resources
     */
    ingredient?: CodeableConcept[];
    /**
     * @description Any component of the drug product which is not the chemical entity defined as the drug substance, or an excipient in the drug product. This includes process-related impurities and contaminants, product-related impurities including degradation products.
     * @short Any component of the drug product which is not the chemical entity defined as the drug substance, or an excipient in the drug product
     */
    impurity?: CodeableReference<SubstanceDefinition>[];
    /**
     * @description Additional information or supporting documentation about the medicinal product.
     * @short Additional documentation about the medicinal product
     */
    attachedDocument?: Reference<DocumentReference>[];
    /**
     * @description A master file for the medicinal product (e.g. Pharmacovigilance System Master File). Drug master files (DMFs) are documents submitted to regulatory agencies to provide confidential detailed information about facilities, processes or articles used in the manufacturing, processing, packaging and storing of drug products.
     * @short A master file for the medicinal product (e.g. Pharmacovigilance System Master File)
     */
    masterFile?: Reference<DocumentReference>[];
    /**
     * @backbone Nested BackboneElement: contact [0..*]
     */
    contact?: MedicinalProductDefinition_Contact[];
    /**
     * @description Clinical trials or studies that this product is involved in.
     * @short Clinical trials or studies that this product is involved in
     */
    clinicalTrial?: Reference<ResearchStudy>[];
    /**
     * @description A code that this product is known by, usually within some formal terminology, perhaps assigned by a third party (i.e. not the manufacturer or regulator). Products (types of medications) tend to be known by identifiers during development and within regulatory process. However when they are prescribed they tend to be identified by codes. The same product may be have multiple codes, applied to it by multiple organizations.
     * @short A code that this product is known by, within some formal terminology
     */
    code?: Coding[];
    /**
     * @backbone Nested BackboneElement: name [1..*]
     */
    name: MedicinalProductDefinition_Name[];
    /**
     * @backbone Nested BackboneElement: crossReference [0..*]
     */
    crossReference?: MedicinalProductDefinition_CrossReference[];
    /**
     * @backbone Nested BackboneElement: operation [0..*]
     */
    operation?: MedicinalProductDefinition_Operation[];
    /**
     * @backbone Nested BackboneElement: characteristic [0..*]
     */
    characteristic?: MedicinalProductDefinition_Characteristic[];
    /**
     * @const Auto-injected fixed value: MedicinalProductDefinition
     */
    resourceType: "MedicinalProductDefinition";
}
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