# LocusZoom.js

### Aggregation Tests Demonstration

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This page demonstrates a mechanism for performing custom aggregation tests interactively, in the web browser. The user can compare several different hypotheses, with contextual visualization to help summarize and interpret the results.

Calculation functionality is provided by raremetal.js.

### Build your analysis

Specify the phenotype (such as "low density lipoprotein"), mask(s), and type(s) of aggregation test to run, for all genes in a specified plot region. Use CTRL-click to select more than one mask or test.

Select phenotype
Select mask(s)
Select test(s)
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### Interactive Plot

Click on any gene to filter the table of aggregation test results to only those for that gene. Click the gene again to unselect and show all aggregation tests across the entire region. Each gene/interval can have more than one mask. The entire set of possible results in a given gene/interval is summarized by color: significant / not significant / no data available.

Invalid position. Must be in chrom:start-end format.

### Table of aggregation test results

Currently reviewing results for group: (all genes in view)

Click on a row in the table below to see the variants associated with a specific mask + gene.

### Variants in mask

### References

- Feng, S., Liu, D., Zhan, X., Wing, M. K., & Abecasis, G. R. (2014). RAREMETAL: fast and powerful meta-analysis for rare variants. Bioinformatics, 30(19), 2828-2829. (link)
- Liu, D. J., Peloso, G. M., Zhan, X., Holmen, O. L., Zawistowski, M., Feng, S. et al. (2014). Meta-analysis of gene-level tests for rare variant association. Nat Genet, 46(2), 200-204. (link)